Department of Biomolecular Nanotechnology


The Paulusse-group develops nanomaterials for early diagnosis and treatment of diseases.

Controlled Drug Delivery

Our uniquely sized polymer nanoparticles in the 5-100 nm size range can encapsulate therapeutics under aqueous conditions, as well as in organic solvent. Moreover, they allow for facile alteration of their surface functionality, giving access to protein mimicking behavior. Current efforts are focused on designing the nanoparticles and evaluating them both in vitro and in vivo, enabling drug delivery and targeted imaging.

Hybrid Imaging Modalities

We have developed new synthesis routes towards silicon nanoparticles, and we are investigating their application as hybrid imaging modality, combining fluorescence and magnetic resonance imaging. High sensitivity multimodal imaging agents can revolutionize medical imaging, by enabling much earlier diagnosis of diseases, expediting their treatment.

Keywords: controlled drug delivery, silicon nanoparticles, polymer nanoparticles, early diagnosis of diseases, hybrid imaging modalities

Dr. Jos Paulusse

University: University of Twente
Department/Institute: Department of Biomolecular Nanotechnology
Street / number: P.O. Box 217                                            

Zipcode City: 7500 AE Enschede                                        
Country: The Netherlands                                         
Phone: 053-489 3306                                     

E-mail: J.M.J.Paulusse(at)